I've been playing this recently and discovered that if you use the advice of turning off origin in game notifications and can get to the point where you can start a skirmish but still run into the issue of not being able to click the bottom right of the screen including some unit production that there is a temporary fix for the duration of your session, idk if it's just my computer but anyways get your skirmish loaded and when your in the match just pause the game and let your screen time out and go black, that's it, when you wiggle your mouse and it comes up, unpause and try clicking a unit in the build menu where you couldnt before and it should work, lemme know if this helps.
